Publications

Selected Publications

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Lisowski P, Lickfett S, Rybak-Wolf A, Le S, Dykstra W, et al., Metzger JJ*, Prigione A*
Mutant Huntingtin impairs neurodevelopment in human brain organoids through CHCHD2-mediated neurometabolic failure, in review
doi.org/10.1101/2023.06.03.543551

Metzger JJ, Pereda C, Adhikari A, Haremaki T, Galgoczi S, Siggia ED, Brivanlou AH, Etoc F
Deep-learning analysis of micropattern-based organoids enables high-throughput drug screening of Huntington’s disease models, Cell Rep. Meth. 2(9), 100297 (2022)
10.1016/j.crmeth.2022.100297

Ray SS, Dutta D, Dennys C, Powers S, Roussel F, Lisowski P, Glažar P, Zhang X, Biswas P, Caporale JR, Rajewsky N, Bickle M, Wein N, Bellen HJ, Likhite S, Marcogliese PC, Meyer KC, Mechanisms of IRF2BPL-related disorders and identification of a potential therapeutic strategy, Cell Rep 41 (10): 111751
10.1016/j.celrep.2022.111751

Yang M, Rito T, Metzger JJ, Naftaly J, Soman R, Hu J, Albertini DF, Barad DH, Brivanlou AH, Gleicher N
Depletion of aneuploid cells in human embryos and gastruloids, Nat. Cell Biol. 23, 4 (2021)
10.1038/s41556-021-00660-7

Galgoczi S, Ruzo A, Markopoulos C, Yoney A, Phan-Everson T, Li S, Haremaki T, Metzger JJ, Etoc F, Brivanlou AH, Huntingtin CAG expansion impairs germ layer patterning in synthetic human 2D gastruloids through polarity defects, Development 184, dev199513 (2021)
10.1242/dev.199513

Haremaki T*, Metzger JJ*, Rito T*, Ozair Z, Etoc F, Brivanlou AH Self-organizing neuruloids model developmental aspects of Huntington’s dis- ease in the ectodermal compartment, Nat. Biotechnol. 37, 1198 (2019)
10.1038/s41587-019-0237-5 

Simunovic M, Metzger JJ, Etoc, F, Yoney A, Ruzo A, Martyn I, Croft G, Brivanlou AH, Siggia ED
Molecular mechanism of symmetry breaking in a 3D model of a human epiblast, Nat. Cell Biol. 21, 900 (2019)
10.1038/s41556-019-0349-7

Ruzo, A*, Croft GF*, Metzger JJ* et al., Chromosomal instability during neurogenesis in Huntington’s disease, Development 145, dev156844 (2018)
10.1242/dev.156844

Morgani S, Metzger JJ, Nichols J, Siggia ED, Hadjantonakis AK, Micropattern differentiation of mouse pluripotent stem cells recapitulates embryo regionalized cell fate patterning, eLife 7:e32839 (2018)
10.7554/eLife.32839

Etoc F, Metzger JJ, Ruzo A, Kirst C, Yoney A, Ozair Z, Brivanlou AH, Siggia ED A balance between secreted inhibitors and edge-sensing controls gastruloid self-organization, Dev. Cell 39, 302 (2018)
10.1016/j.devcel.2016.09.016

Deglincerti A*, Etoc F*, Guerra M*, Martyn I*, Metzger JJ*, Ruzo A*, Simunovic M*, Brivanlou A, Siggia E, Warmflash A, Self-organization of human embryonic stem cells on micropatterns, Nat. Protocols, 11, 2223 (2016)
10.1038/nprot.2016.131